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In evolutionary biology, the GARD (Graded Autocatalysis Replication Domain) model is a general kinetic model for homeostatic-growth and fission of compositional-assemblies, with specific application towards lipids. In the context of abiogenesis, the lipid-world suggests assemblies of simple molecules, such as lipids, can store and propagate information, thus undergo evolution. These 'compositional assemblies' have been suggested to play a role in the origin of life. The idea is the information being transferred throughout the generations is '' compositional information '' – the different types and quantities of molecules within an assembly. This is different from the information encoded in RNA or DNA, which is the specific sequence of bases in such molecule. Thus, the model is viewed as an alternative or an ancestor to the RNA world hypothesis. ==The GARD model== The composition vector of an assembly is written as: . Where are the molecular counts of lipid type ''i'' within the assembly, and NG is how many different lipid types exist (''repertiore size''). The change in the count of molecule type ''i'' is described by: : and are the basel forward (joining) and backward (leaving) rate constants, ''β''''ij'' is a non-negative rate enhancement exerted by molecule type ''j'' within the assembly on type ''i'' from the environment, and ρ is the environmental concentration of each molecule type. The assembly current size is . The system is kept away from equilibrium by imposing a fission action once the assembly reaches a maximal size, Nmax, usually in the order of NG. This splitting action produces two progeny of same size, and one of which is grown again. The model is subjected to a Monte Carlo algorithm based simulations, using Gillespie algorithm. 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Gard model」の詳細全文を読む スポンサード リンク
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